profile

Metin Bilgin

Research Scientist -Project Lead

Urbana, 61801, USA

Skills

Omics Technologies

Assay Development

Protein Expression

Problem solving

About

Innovative molecular, cellular biologist and biochemist with >10 years of post-graduate experience in molecular biology, assay development, protein expression/purification and characterization; interactive proteomics, plant transgenics and discovery driven research Co-developed the first proteome chip and assay protocols for protein microarray technology • Expert in –omics technologies, DNA/RNA analytics, quantitative PCR methods, , recombinant DNA technologies, recombinant /native protein expression/ purification, miniaturized enzymatic (hydrolase, esterase, protein kinase, P450 monooxygenase) assays, activity based fingerprinting, protein/reverse phase antibody capture microarrays, antibody purification, conjugation and immunoassay optimization; molecular interactions of small molecules, high throughput multiplexed molecular/cell based assay development , and automated liquid handling • Experienced in yeast, plant and mammalian experimental systems o Supervisory/managerial (PI) experience in academics and research park (start-up) o “Entrepreneurship and Life Sciences Management “ Business certificate degree o Experienced in training, writing reports/ grant proposals, presenting data, preparing and managing Intellectual Property applications o Proficient in Project management (time, cost and resource management) o Highly trained in analytical and critical thinking and troubleshooting o Open minded for new technologies, analytical techniques across disciplines. o Experienced in collaborative projects and scientific affairs management

Education

Szeged University

Molecular Biology , Molecular Biology

May 2001 - May 2001

METU

Genetics , Genetics

June 1992 - June 1992

Experience

Laboratory Manager

EnterpriseWorks , Urbana, IL

May 2011 - August 2012

Provide R&D logistics, analytical instrument training, solve technical problems for start-up companies

Management
Training
ex: PHP
Project scientist

University of Illinois at Urbana-Champaign

May 2011 - August 2012

Molecular characterization of a small molecule biofungicide

Research
Project Management
Grant writing
Postdoctoral Research Associate

University of Illinois at Urbana-Champaign

January 2006 - April 2011

Regulation of cytochrome P450 biosynthesis by nuclear hormone receptors Molecular mechanisms of CAR activity in hepatocytes. Purification and functional/structural characterization of phenobarbital induced chromatin-protein complexes by tandem affinity purification, antibody capture protein interaction arrays, in situ/in solution PLA and LC-MS/MS. Molecular genetic characterization of enhancer sequences of Cyp2b10 regulatory sequences

Research
Undergraduate training
ex: PHP
Post Doctoral Research Associate

University of Illinois at Urbana-Champaign

October 2004 - December 2006

Functional, biochemical genomics and structural characterization of Arabidopsis cytochrome P450 Enzymes Studied chemical stress/xenobiotic induced P450 gene regulation by expression profiling with DNA microarrays and qRT-PCR. Cloned full length P450 cDNAs, expressed recombinant P450 genes in Sf9 cells for substrate determination and kinetic studies. Isolated several corresponding T-DNA loss-of function mutants sensitive to xenobiotics and various stresses. Identified a putative promoter element involved in regulating xenobiotic metabolism and oxidative stress responses in Arabidopsis.

Research
Training
ex: PHP
Assistant professor

Sabanci University

July 2001 - July 2004

Conducted research on molecular characterization of plant lipases towards their use in industrial enzymatic processes. Prepared and presented lectures, developed student research practicals, trained teaching assistants, evaluated and graded student performances. All lectures listed below are given in English. • BIO403 Analytical Techniques, Fall 2002 , • BIO521 Functional Genomics, Proteomics and Bioinformatics, Spring 2003, • BIO310 Genetics, Fall 2002, Fall 2003 • BIO407 Multicellular Organizations, Fall 2003, • Project 102 “Design of DNA microarray”, Spring 2003,

Research
Teaching
Project Management/Consulting
Post Doctoral Research Associate

Yale University

July 1999 - August 2001

Principal Investigators: Prof. Steven Dellaporta and Prof. Michael Snyder Protein arrays: Spearheaded efforts to clone, express, purify and analyze binding activities of ~6200 S.cerevisiae proteins on a miniaturized array format. Developed optimized high-throughput methods for expression and purification of tagged or native proteins. Established differential screening method for post-translational modification (glycosylation) based on lectin binding. Reverse genetics in Arabidopsis ; T-DNA knockout analysis: Developed analysis tools and reagents for high-throughput analysis of T-DNA knockout lines for Arabidopsis Functional Genomics Consortium. For reverse genetic screens, macroarrays were developed using liquid handling robotic instruments. Subsequently, identified mutant lines of several members of the bZIP family transcription factors involved in developmental control of cell death.

Research
ex: Gardening
ex: PHP

Workplace personality

100+

Company Size

12

Day Length

25+

Team Size

Loud

Noise Level

Formal

Dress Code

Benefits

Gym

Relocate

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